The clinical application potential of extracellular matrix in cardiac tissue engineering
نویسندگان
چکیده
منابع مشابه
Reinforcement of a decellularized extracellular matrix-derived hydrogel using nanofibers for cardiac tissue engineering
The role of heart disease in increasing worldwide death and the limited availability of organs for transplantation have encouraged multiple strategies to fabricate functional and implantable constructs. One of these strategies is to develop a biologically similar heart tissue scaffold, in which two types of fiber and hydrogel are commonly used. Toward this goal, taking advantage of both hydroge...
متن کاملReinforcement of a decellularized extracellular matrix-derived hydrogel using nanofibers for cardiac tissue engineering
The role of heart disease in increasing worldwide death and the limited availability of organs for transplantation have encouraged multiple strategies to fabricate functional and implantable constructs. One of these strategies is to develop a biologically similar heart tissue scaffold, in which two types of fiber and hydrogel are commonly used. Toward this goal, taking advantage of both hydroge...
متن کاملVascularisation for cardiac tissue engineering: the extracellular matrix.
Cardiovascular diseases present a major socio-economic burden. One major problem underlying most cardiovascular and congenital heart diseases is the irreversible loss of contractile heart muscle cells, the cardiomyocytes. To reverse damage incurred by myocardial infarction or by surgical correction of cardiac malformations, the loss of cardiac tissue with a thickness of a few millimetres needs ...
متن کاملExtracellular Matrix Revisited: Roles in Tissue Engineering
[This corrects the article on p. S23 in vol. 20, PMID: 27230457.].
متن کاملPushing the Envelope in Tissue Engineering: Ex Vivo Production of Thick Vascularized Cardiac Extracellular Matrix Constructs
Functional vascularization is a prerequisite for cardiac tissue engineering of constructs with physiological thicknesses. We previously reported the successful preservation of main vascular conduits in isolated thick acellular porcine cardiac ventricular ECM (pcECM). We now unveil this scaffold's potential in supporting human cardiomyocytes and promoting new blood vessel development ex vivo, pr...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2015
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2015.08.007